Dayong applies his technical expertise in computer sciences, biomedical research and pharmaceuticals to intellectual property analysis and counseling. Dayong received his Ph.D. in biology and computer sciences from the University of Missouri-Kansas City. Before joining Shook, he held a bioinformatics scientist position at Regeneron Pharmaceuticals designing humanized models for antibody drug development. He also held a research position at the School of Dentistry, University of Missouri-Kansas City focusing on the proteomics and genomics of mineralized tissues. His research interests are in the field of bioinformatics, software engineering and genetic disease modeling.
Publications
Prideaux M, Dallas SL, Zhao N, Johnsrud ED, Veno PA, Guo D, et al. Parathyroid hormone induces bone cell motility and loss of mature osteocyte phenotype through L-calcium channel dependent and independent mechanisms. PLoS ONE. May 2015;10(5):e0125731.
Guo D, Online high-throughput gene mutagenesis designer using Cas9 RNA-directed endonucleases (http://cas9.wicp.net). China National Copyright Administration. Aug 2014; Software Certificate No.0791292.
Yang W, Guo D, et al., Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells. J Cell Sci.2013;126(18):4085-98.
Guo D, Keightley A, Guthrie J, Veno P, Harris S, Bonewald L. Identification of osteocyte-selective proteins. Proteomics. Oct 2010;10(20):3688-98.
Hwang C, Guo D, Harris M, Howard O, Mishina Y, Gan L, Harris S, Wu D. Role of bone morphogenetic proteins on cochlear hair cell formation: analyses of Noggin and Bmp2 mutant mice. Dev Dyn. Feb 2010;239(2):505-13.
Gluhak-Heinrich J, Guo D, Yang W, Harris MA, Lichtler A, Kream B, Zhang J, Feng JQ, Smith LC, Dechow P, Harris SE. New roles and mechanism of action of BMP4 in postnatal tooth cytodifferentiation. Bone. 2010 Jun;46(6):1533-45.
Yang W, Harris MA, Heinrich JG, Guo D, Bonewald LF, Harris SE. Gene expression signatures of a fibroblastoid preosteoblast and cuboidal osteoblast cell model compared to the MLO-Y4 osteocyte cell model. Bone. 2009 Jan;44(1):32-45.
Guo D, Bonewald L. Advancing our understanding of osteocyte cell biology. Therapeutic Advances in Musculoskeletal Disease. December 2009 vol. 1 no. 2 87-96
Singh AP, Castranio T, Scott G, Guo D, Harris MA, Ray M, Harris SE, Mishina Y. Influences of reduced expression of maternal bone morphogenetic protein 2 on mouse embryonic development. Sex Dev. 2008;2(3):134-41.
Gluhak-Heinrich J, Guo D, Yang W, Martinez L, Harris M, Kulessa H, Lichtler A, Kream B, Zhang J, Feng J, Harris S. The role of bone morphogenetic protein 4 (BMP-4) in tooth development. Bone morphogenetic proteins: from local to systemic therapeutics, progress in inflammation research. ISBN 978-3-7643-8551-4. 2008;179-212.
Feng JQ, Scott G, Guo D, Jiang B, Harris M, Ward T, Ray M, Bonewald LF, Harris SE, Mishina Y. Generation of a conditional null allele for Dmp1 in mouse. Genesis. 2008;46(2):87-91.
Xiao Z, Zhang S, Malios J, Zhou G, Magenheimer BS, Guo D, Dallas SL, Maser R, Calvet JP, Bonewald L, Quarles LD. Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and runx2 expression. J Biol Chem. 2006.
Yang W, Lu Y, Kalajzic I, Guo D, Harris MA, Gluhak-Heinrich J, Kotha S, Bonewald LF, Feng JQ, Rowe DW, Turner CH, Robling AG, Harris SE. Dentin matrix protein 1 gene cis-regulation: use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo. J Biol Chem. 2005;280(21):20680-90.
Yang W, Kalajzic I, Lu Y, Guo D, Harris MA, Gluhak-Heinrich J, Bonewald LF, Feng JQ, Rowe DW, Harris SE. In vitro and in vivo study on osteocyte-specific mechanical signaling pathways. J Musculoskelet Neuronal Interact. 2004;4(4):386-7.
Kalajzic I, Braut A, Guo D, Jiang X, Kronenberg MS, Mina M, Harris MA, Harris SE, Rowe DW. Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene. Bone. 2004; 35(1):74-82.
Harris SE, Guo D, Harris MA, Krishnaswamy A, Lichtler A. Transcriptional regulation of BMP-2 activated genes in osteoblasts using gene expression microarray analysis: role of Dlx2 and Dlx5 transcription factors. Front Biosci. 2003;8:s1249-65.
Zhang J, Tan X, Contag CH, Lu Y, Guo D, Harris SE, Feng JQ. Dissection of promoter control modules that direct Bmp4 expression in the epithelium-derived components of hair follicles. Biochem Biophys Res Commun. 2002;293(5):1412-9.
Feng JQ, Zhang J, Tan X, Lu Y, Guo D, Harris SE. Identification of cis-DNA regions controlling Bmp4 expression during tooth morphogenesis in vivo. J Dent Res.2002;81(1):6-10.