Zach uses his extensive background in science and technology for the preparation and prosecution of utility applications. His undergraduate, graduate and post-doctoral experience involved overcoming biological and medicinal challenges through the use of synthetic organic chemistry. After earning his doctorate, Zach entered academe and taught for 10 years, reaching the rank of full professor at Nevada State College. His academic research focused on the development of novel fluorophore systems and molecular probes. Zach's research interests are in synthetic organic chemistry, drug design/development, interactions of light with matter, and molecular biology, though he handles intellectual property from a range of different technological areas.
* U.S. Patent and Trademark Office Admission Pending
Improving the Brightness of Pyronin Fluorophore Systems through Computer Modeling Predictions, J. Phys. Chem. Lett. 2022, 13, 8312-8313 (with B. Walls, C. Arambula, A. Hall, F. Boumelhum and S. Odoh).
Synthesis of a Fluorinated Pyronin that Enables Blue Light to Rapidly Depolarize Mitochondria, RSC Med. Chem., 2022, 13, 456-462 (with Z. Gao, K.K. Sharma, A.E. Andres, B. Walls, F. Boumelhem and B.R. Peterson).
Synthesis of Rhodamines and Rosamines Using 3,6- Difluoroxanthone as a Common Intermediate, J. Org. Chem. 2021, 86 (24), 17856-17865 (with C. Arambula, J. Rodrigues and J.J. Koh).
Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Analogues Using a Claisen-Schmidt Condensation Approach, JoVE 2021, 92, 1221–1225 (with N. Benson and A. Davis).
Tautomycetin Synthetic Analogs: Selective Inhibitors of Protein Phosphatase l, ChemMedChem 2020, 16, 839-850 (with A. Yucel and A.R. Chamberlin).
Pyrazole, Imidazole, and Isoindolone Dipyrrinone Analogs: pH Dependent Fluorophores that Red-Shift Emission Frequencies in Basic Solution, J. Org. Chem. 2019, 84, 11856- 11862 (with N. Benson, J. Dean and S. Odoh).
A General Method for Nucleophilic Aromatic Substitution of Aryl Fluorides and Chlorides with Dimethylamine using Hydroxide Assisted Decomposition of N,N-Dimethylforamide, Synthetic Communications 2016, 46, 475–481 (with J. Garcia, J. Sorrentino, E. Diller and D. Chapman).
Synthesis of a Fluorescent Acridone Using a Grignard Addition, Oxidation, and Nucleophilic Aromatic Substitution Reaction Sequence, J. Chem. Ed. 2015, 92, 1221–1225 (with S. Goodrich and M. Patel).
Detection of Protein—Protein Interactions by Proximity-Driven SNAr Reactions of Lysine-Linked Fluorophores, J. Am. Chem. Soc. 2014, 136, 5241–5244 (with D.H. Hymel and B.R. Peterson).
Efficient and Scalable Synthesis of 4-Carboxy-Pennsylvania Green Methyl Ester: A Hydrophobic Building Block for Fluorescent Molecular Probes, Synthesis 2014, 46, 158-164 (with L. Fu and B.R. Peterson).
Synthesis of Fluorinated Benzophenones, Xanthones, Acridones, and Thioxanthones by Iterative Nucleophilic Aromatic Substitution, J. Org. Chem. 2012, 77, 473-481 (with L. Fu and B.R. Peterson).